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==NMR assignments and solution structure of the JAK interaction region of SOCS5==
==NMR assignments and solution structure of the JAK interaction region of SOCS5==
<StructureSection load='2n34' size='340' side='right' caption='[[2n34]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2n34' size='340' side='right'caption='[[2n34]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2n34]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2mp6 2mp6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N34 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2n34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2mp6 2mp6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N34 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n34 RCSB], [http://www.ebi.ac.uk/pdbsum/2n34 PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n34 OCA], [https://pdbe.org/2n34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n34 RCSB], [https://www.ebi.ac.uk/pdbsum/2n34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n34 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SOCS5_MOUSE SOCS5_MOUSE]] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.<ref>PMID:12242343</ref>
[https://www.uniprot.org/uniprot/SOCS5_MOUSE SOCS5_MOUSE] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.<ref>PMID:12242343</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2n34" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Babon, J]]
[[Category: Large Structures]]
[[Category: Chandrashekaran, I R]]
[[Category: Mus musculus]]
[[Category: Dagley, L F]]
[[Category: Babon J]]
[[Category: Leung, E W.W]]
[[Category: Chandrashekaran IR]]
[[Category: Linossi, E M]]
[[Category: Dagley LF]]
[[Category: Mohanty, B]]
[[Category: Leung EWW]]
[[Category: Murphy, J M]]
[[Category: Linossi EM]]
[[Category: Nicholson, S E]]
[[Category: Mohanty B]]
[[Category: Norton, R S]]
[[Category: Murphy JM]]
[[Category: Intrinsically unstructured protein]]
[[Category: Nicholson SE]]
[[Category: Jak interaction region]]
[[Category: Norton RS]]
[[Category: Signaling protein]]
[[Category: Suppressor of cytokine signalling]]
Retrieved from "https://proteopedia.org/2n34"