5cw3: Difference between revisions
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New page: '''Unreleased structure''' The entry 5cw3 is ON HOLD Authors: Zeqiraj, E. Description: Structure of a metal dependent enzyme CFBRCC36 Category: Unreleased Structures [[Category: Ze... |
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==Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge)== | |||
<StructureSection load='5cw3' size='340' side='right'caption='[[5cw3]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_floridanus Camponotus floridanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CW3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Zeqiraj | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw3 OCA], [https://pdbe.org/5cw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cw3 RCSB], [https://www.ebi.ac.uk/pdbsum/5cw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw3 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRCC3_CAMFO BRCC3_CAMFO] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity (PubMed:26344097). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).[UniProtKB:Q15018][UniProtKB:Q3TCJ1]<ref>PMID:26344097</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Camponotus floridanus]] | |||
[[Category: Large Structures]] | |||
[[Category: Zeqiraj E]] | |||
Latest revision as of 12:21, 6 March 2024
Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge)
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