5cw5: Difference between revisions

(5 intermediate revisions by the same user not shown)

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5cw5 is ~~ON HOLD~~

==Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant)==

~~Authors~~: ~~Zeqiraj~~, E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5cw5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_floridanus Camponotus floridanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CW5 FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~metal dependent enzyme CfBRCC36~~, ~~CfKIAA0157~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.736Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw5 OCA], [https://pdbe.org/5cw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cw5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw5 ProSAT]</span></td></tr>

[[Category: Zeqiraj, E]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/BRCC3_CAMFO BRCC3_CAMFO] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity (PubMed:26344097). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).[UniProtKB:Q15018][UniProtKB:Q3TCJ1]<ref>PMID:26344097</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Camponotus floridanus]]

[[Category: Large Structures]]

[[Category: Zeqiraj E]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5cw5 is ON HOLD
+==Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant)==
+<StructureSection load='5cw5' size='340' side='right'caption='[[5cw5]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
-Authors: Zeqiraj, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cw5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_floridanus Camponotus floridanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CW5 FirstGlance]. <br>
-Description: Structure of metal dependent enzyme CfBRCC36, CfKIAA0157
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.736&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw5 OCA], [https://pdbe.org/5cw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cw5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw5 ProSAT]</span></td></tr>
-[[Category: Zeqiraj, E]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BRCC3_CAMFO BRCC3_CAMFO] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity (PubMed:26344097). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).[UniProtKB:Q15018][UniProtKB:Q3TCJ1]<ref>PMID:26344097</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Camponotus floridanus]]
+[[Category: Large Structures]]
+[[Category: Zeqiraj E]]