5cyo: Difference between revisions
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New page: '''Unreleased structure''' The entry 5cyo is ON HOLD Authors: Matos, S.S, Leonardo, D.A., Pereira, H.M., Araujo, A.P.U., Garratt, R.C. Description: High resolution Septin 9 GTPase doma... |
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==High resolution Septin 9 GTPase domain in complex with GDP== | |||
<StructureSection load='5cyo' size='340' side='right'caption='[[5cyo]], [[Resolution|resolution]] 2.04Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CYO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0354Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: Garratt | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyo OCA], [https://pdbe.org/5cyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cyo RCSB], [https://www.ebi.ac.uk/pdbsum/5cyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyo ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: Matos | [https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref> The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Araujo APU]] | |||
[[Category: Garratt RC]] | |||
[[Category: Horjales E]] | |||
[[Category: Leonardo DA]] | |||
[[Category: Matos SS]] | |||
[[Category: Pereira HM]] | |||
Latest revision as of 12:22, 6 March 2024
High resolution Septin 9 GTPase domain in complex with GDP
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