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==Deerpox virus DPV022 in complex with Bak BH3==
==Deerpox virus DPV022 in complex with Bak BH3==
<StructureSection load='4uf1' size='340' side='right' caption='[[4uf1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4uf1' size='340' side='right'caption='[[4uf1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uf1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UF1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uf1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deerpox_virus_W-1170-84 Deerpox virus W-1170-84] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UF1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uf2|4uf2]], [[4uf3|4uf3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uf1 RCSB], [http://www.ebi.ac.uk/pdbsum/4uf1 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf1 OCA], [https://pdbe.org/4uf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uf1 RCSB], [https://www.ebi.ac.uk/pdbsum/4uf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uf1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
[https://www.uniprot.org/uniprot/DPV22_DPV83 DPV22_DPV83] Plays a role in the inhibition of host apoptosis by sequestering and inactivating several proapoptotic BCL-2 proteins, including BAK1 and BAX. Prevents the conformational activation of both of them.<ref>PMID:21159883</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Burton, D R]]
[[Category: Deerpox virus W-1170-84]]
[[Category: Kvansakul, M]]
[[Category: Homo sapiens]]
[[Category: Apoptosis]]
[[Category: Large Structures]]
[[Category: Bak bh3]]
[[Category: Burton DR]]
[[Category: Bcl-2]]
[[Category: Kvansakul M]]
[[Category: Deerpox virus]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/4uf1"