5cw6: Difference between revisions

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'''Unreleased structure'''


The entry 5cw6 is ON HOLD  until Paper Publication
==Structure of metal dependent enzyme DrBRCC36==
 
<StructureSection load='5cw6' size='340' side='right'caption='[[5cw6]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
Authors: Zeqiraj, E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5cw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CW6 FirstGlance]. <br>
Description: Structure of metal dependent enzyme DrBRCC36
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.193&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Zeqiraj, E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw6 OCA], [https://pdbe.org/5cw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cw6 RCSB], [https://www.ebi.ac.uk/pdbsum/5cw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A8M3B525_DANRE A0A8M3B525_DANRE] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.[RuleBase:RU367116]
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Zeqiraj E]]
Retrieved from "https://proteopedia.org/5cw6"