5d8f: Difference between revisions
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New page: '''Unreleased structure''' The entry 5d8f is ON HOLD Authors: Li, Y.H., Gao, Z.Q., Dong, Y.H. Description: crystal structure of SSB and ssDNA complex from homo sapiens [[Category: Unre... |
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==crystal structure of SSB and ssDNA complex from homo sapiens== | |||
<StructureSection load='5d8f' size='340' side='right'caption='[[5d8f]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5d8f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D8F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8f OCA], [https://pdbe.org/5d8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d8f RCSB], [https://www.ebi.ac.uk/pdbsum/5d8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref> | |||
==See Also== | |||
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Dong YH]] | |||
[[Category: Gao ZQ]] | |||
[[Category: Li YH]] | |||
Latest revision as of 16:15, 8 November 2023
crystal structure of SSB and ssDNA complex from homo sapiens
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