5d9h: Difference between revisions

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New page: '''Unreleased structure''' The entry 5d9h is ON HOLD Authors: Taylor, C.A., Juang, Y.C., Goldsmith, E.J., Cobb, M.H. Description: Crystal structure of SPAK (STK39) dimer in the basal a...
 
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'''Unreleased structure'''


The entry 5d9h is ON HOLD
==Crystal structure of SPAK (STK39) dimer in the basal activity state==
<StructureSection load='5d9h' size='340' side='right'caption='[[5d9h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5d9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D9H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9h OCA], [https://pdbe.org/5d9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d9h RCSB], [https://www.ebi.ac.uk/pdbsum/5d9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STK39_MOUSE STK39_MOUSE] May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).<ref>PMID:21317537</ref> <ref>PMID:23542070</ref>


Authors: Taylor, C.A., Juang, Y.C., Goldsmith, E.J., Cobb, M.H.
==See Also==
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
Description: Crystal structure of SPAK (STK39) dimer in the basal activity state
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Juang, Y.C]]
__TOC__
[[Category: Taylor, C.A]]
</StructureSection>
[[Category: Cobb, M.H]]
[[Category: Large Structures]]
[[Category: Goldsmith, E.J]]
[[Category: Mus musculus]]
[[Category: Cobb MH]]
[[Category: Goldsmith EJ]]
[[Category: Juang YC]]
[[Category: Taylor CA]]
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