5d9h: Difference between revisions
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==Crystal structure of SPAK (STK39) dimer in the basal activity state== | |||
<StructureSection load='5d9h' size='340' side='right'caption='[[5d9h]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5d9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D9H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9h OCA], [https://pdbe.org/5d9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d9h RCSB], [https://www.ebi.ac.uk/pdbsum/5d9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/STK39_MOUSE STK39_MOUSE] May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).<ref>PMID:21317537</ref> <ref>PMID:23542070</ref> | |||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Cobb MH]] | |||
[[Category: Goldsmith EJ]] | |||
[[Category: Juang YC]] | |||
[[Category: Taylor CA]] | |||
Latest revision as of 12:23, 6 March 2024
Crystal structure of SPAK (STK39) dimer in the basal activity state
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