5dah: Difference between revisions
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New page: '''Unreleased structure''' The entry 5dah is ON HOLD Authors: Chen, S., Patel, D.J. Description: Crystal structure of PZP domain of human AF10 protein fused with Histone H3 peptide [[C... |
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==Crystal structure of PZP domain of human AF10 protein fused with Histone H3 peptide== | |||
<StructureSection load='5dah' size='340' side='right'caption='[[5dah]], [[Resolution|resolution]] 2.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dah]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DAH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.611Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dah OCA], [https://pdbe.org/5dah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dah RCSB], [https://www.ebi.ac.uk/pdbsum/5dah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dah ProSAT]</span></td></tr> | ||
[[Category: Chen | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN] Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.<ref>PMID:17868029</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen S]] | |||
[[Category: Patel DJ]] | |||
Latest revision as of 12:23, 6 March 2024
Crystal structure of PZP domain of human AF10 protein fused with Histone H3 peptide
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