5dc3: Difference between revisions

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'''Unreleased structure'''


The entry 5dc3 is ON HOLD
==Complex of yeast 80S ribosome with non-modified eIF5A==
<StructureSection load='5dc3' size='340' side='right'caption='[[5dc3]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dc3]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DC3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dc3 OCA], [https://pdbe.org/5dc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dc3 RCSB], [https://www.ebi.ac.uk/pdbsum/5dc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dc3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here we report a 3.25A-resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A-ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A-ribosome association.


Authors: Melnikov, S., Mailliot, J., Shin, B.-S., Rigger, L., Yusupova, G., Micura, R., Dever, T.E., Yusupov, M.
Crystal structure of hypusine-containing translation factor eIF5A bound to a rotated eukaryotic ribosome.,Melnikov S, Mailliot J, Shin BS, Rigger L, Yusupova G, Micura R, Dever TE, Yusupov M J Mol Biol. 2016 May 16. pii: S0022-2836(16)30154-1. doi:, 10.1016/j.jmb.2016.05.011. PMID:27196944<ref>PMID:27196944</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Mailliot, J]]
<div class="pdbe-citations 5dc3" style="background-color:#fffaf0;"></div>
[[Category: Yusupov, M]]
 
[[Category: Micura, R]]
==See Also==
[[Category: Yusupova, G]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
[[Category: Shin, B.-S]]
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
[[Category: Melnikov, S]]
== References ==
[[Category: Rigger, L]]
<references/>
[[Category: Dever, T.E]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Dever TE]]
[[Category: Mailliot J]]
[[Category: Melnikov S]]
[[Category: Micura R]]
[[Category: Rigger L]]
[[Category: Shin B-S]]
[[Category: Yusupov M]]
[[Category: Yusupova G]]
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