5dcy: Difference between revisions
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New page: '''Unreleased structure''' The entry 5dcy is ON HOLD Authors: Caputi, L., Kries, H., Stevenson, C.E.M., Kamileen, M.O., Sherden, N.H., Geu-Flores, F., Lawson, D.M., O'Connor, S.E. Desc... |
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The | ==Iridoid synthase G150A mutant from Catharanthus roseus - binary complex with NADP+== | ||
<StructureSection load='5dcy' size='340' side='right'caption='[[5dcy]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Catharanthus_roseus Catharanthus roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DCY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dcy OCA], [https://pdbe.org/5dcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dcy RCSB], [https://www.ebi.ac.uk/pdbsum/5dcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dcy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IRIS_CATRO IRIS_CATRO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5beta-reductase are highlighted. | |||
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.,Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE Nat Chem Biol. 2015 Nov 9. doi: 10.1038/nchembio.1955. PMID:26551396<ref>PMID:26551396</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5dcy" style="background-color:#fffaf0;"></div> | ||
[[Category: Geu-Flores | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: O'Connor | [[Category: Catharanthus roseus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Caputi L]] | ||
[[Category: Geu-Flores F]] | |||
[[Category: Kamileen MO]] | |||
[[Category: Kries H]] | |||
[[Category: Lawson DM]] | |||
[[Category: O'Connor SE]] | |||
[[Category: Sherden NH]] | |||
[[Category: Stevenson CEM]] | |||
Latest revision as of 11:25, 10 January 2024
Iridoid synthase G150A mutant from Catharanthus roseus - binary complex with NADP+
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