5amt: Difference between revisions
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==Intracellular growth locus protein E== | |||
<StructureSection load='5amt' size='340' side='right'caption='[[5amt]], [[Resolution|resolution]] 1.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5amt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._novicida Francisella tularensis subsp. novicida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amt OCA], [https://pdbe.org/5amt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amt RCSB], [https://www.ebi.ac.uk/pdbsum/5amt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0Q7H2_FRATN A0Q7H2_FRATN] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Tularaemia is an uncommon but potentially dangerous zoonotic disease caused by the bacterium Francisella tularensis. As few as ten bacterial cells are sufficient to cause disease in a healthy human, making this one of the most infectious disease agents known. The virulence of this organism is dependent upon a genetic locus known as the Francisella pathogenicity island (FPI), which encodes components of a secretion system that is related to the type VI secretion system. Here, the cloning, expression, purification and preliminary X-ray diffraction statistics of the FPI-encoded protein IglE are presented. This putative lipoprotein is required for intra-macrophage growth and is thought to be a constituent of the periplasmic portion of the type VI-like protein complex that is responsible for the secretion of critical virulence factors in Francisella. | |||
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of intracellular growth locus E (IglE) protein from Francisella tularensis subsp. novicida.,Robb CS, Nano FE, Boraston AB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1596-8., doi: 10.1107/S1744309110034378. Epub 2010 Nov 25. PMID:21139203<ref>PMID:21139203</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5amt" style="background-color:#fffaf0;"></div> | ||
[[Category: Boraston | == References == | ||
[[Category: Nano | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Francisella tularensis subsp. novicida]] | |||
[[Category: Large Structures]] | |||
[[Category: Boraston AB]] | |||
[[Category: Nano FE]] | |||
[[Category: Robb CS]] | |||
Latest revision as of 11:42, 9 May 2024
Intracellular growth locus protein E
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