5awc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5awc is ON HOLD  until Paper Publication
==Crystal structure of human TLR8 in complex with MB-564==
<StructureSection load='5awc' size='340' side='right'caption='[[5awc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5awc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AWC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=M4D:5-(4-AZANYLBUTYL)-3-PENTYL-QUINOLIN-2-AMINE'>M4D</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awc OCA], [https://pdbe.org/5awc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5awc RCSB], [https://www.ebi.ac.uk/pdbsum/5awc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5awc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>


Authors: Tanji, H., Ohto, U., Shimizu, T.
==See Also==
 
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
Description: Crystal structure of human TLR8 in complex with MB-564
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Tanji, H]]
__TOC__
[[Category: Shimizu, T]]
</StructureSection>
[[Category: Ohto, U]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ohto U]]
[[Category: Shimizu T]]
[[Category: Tanji H]]
Retrieved from "https://proteopedia.org/5awc"