5dkg: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5dkg" [edit=sysop:move=sysop] |
No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a t-butyl-substituted, methyl, triaryl-ethylene derivative 4,4'-[2-(4-tert-butylphenyl)prop-1-ene-1,1-diyl]diphenol== | |||
<StructureSection load='5dkg' size='340' side='right'caption='[[5dkg]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dkg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5C7:4,4-[2-(4-TERT-BUTYLPHENYL)PROP-1-ENE-1,1-DIYL]DIPHENOL'>5C7</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dkg OCA], [https://pdbe.org/5dkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dkg RCSB], [https://www.ebi.ac.uk/pdbsum/5dkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dkg ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref> | |||
==See Also== | |||
*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Carlson KE]] | ||
[[Category: | [[Category: Cavett V]] | ||
[[Category: | [[Category: Dong C]] | ||
[[Category: | [[Category: Elemento O]] | ||
[[Category: | [[Category: Houtman R]] | ||
[[Category: | [[Category: Josan JS]] | ||
[[Category: | [[Category: Katzenellenbogen JA]] | ||
[[Category: | [[Category: Liao Z]] | ||
[[Category: | [[Category: Min J]] | ||
[[Category: | [[Category: Nettles KW]] | ||
[[Category: | [[Category: Nowak J]] | ||
[[Category: | [[Category: Nwachukwu JC]] | ||
[[Category: Srinivasan S]] | |||
[[Category: Wang S]] | |||
[[Category: Zheng Y]] | |||
[[Category: Zhou HB]] | |||
Latest revision as of 12:25, 6 March 2024
Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a t-butyl-substituted, methyl, triaryl-ethylene derivative 4,4'-[2-(4-tert-butylphenyl)prop-1-ene-1,1-diyl]diphenol
| ||||||||||||
