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[[Image:1jjv.gif|left|200px]]


{{Structure
==DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP==
|PDB= 1jjv |SIZE=350|CAPTION= <scene name='initialview01'>1jjv</scene>, resolution 2.&Aring;
<StructureSection load='1jjv' size='340' side='right'caption='[[1jjv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene> and <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>
<table><tr><td colspan='2'>[[1jjv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JJV FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dephospho-CoA_kinase Dephospho-CoA kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE= YacE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjv OCA], [https://pdbe.org/1jjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jjv RCSB], [https://www.ebi.ac.uk/pdbsum/1jjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jjv ProSAT]</span></td></tr>
 
</table>
'''DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP'''
== Function ==
 
[https://www.uniprot.org/uniprot/COAE_HAEIN COAE_HAEIN] Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity).
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
Dephospho-coenzyme A kinase catalyzes the final step in CoA biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. The protein from Haemophilus influenzae was cloned and expressed, and its crystal structure was determined at 2.0-A resolution in complex with ATP. The protein molecule consists of three domains: the canonical nucleotide-binding domain with a five-stranded parallel beta-sheet, the substrate-binding alpha-helical domain, and the lid domain formed by a pair of alpha-helices. The overall topology of the protein resembles the structures of nucleotide kinases. ATP binds in the P-loop in a manner observed in other kinases. The CoA-binding site is located at the interface of all three domains. The double-pocket structure of the substrate-binding site is unusual for nucleotide kinases. Amino acid residues implicated in substrate binding and catalysis have been identified. The structure analysis suggests large domain movements during the catalytic cycle.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/1jjv_consurf.spt"</scriptWhenChecked>
1JJV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJV OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae., Obmolova G, Teplyakov A, Bonander N, Eisenstein E, Howard AJ, Gilliland GL, J Struct Biol. 2001 Nov;136(2):119-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11886213 11886213]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jjv ConSurf].
[[Category: Dephospho-CoA kinase]]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bonander, N.]]
[[Category: Bonander N]]
[[Category: Eisenstein, E.]]
[[Category: Eisenstein E]]
[[Category: Gilliland, G L.]]
[[Category: Gilliland GL]]
[[Category: Howard, A J.]]
[[Category: Howard AJ]]
[[Category: Obmolova, G.]]
[[Category: Obmolova G]]
[[Category: S2F, Structure 2.Function Project.]]
[[Category: Teplyakov A]]
[[Category: Teplyakov, A.]]
[[Category: ATP]]
[[Category: HG]]
[[Category: SO4]]
[[Category: p-loop nucleotide-binding fold]]
[[Category: s2f]]
[[Category: structural genomic]]
[[Category: structure 2 function project]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:21:32 2008''

Latest revision as of 07:40, 7 February 2024

DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP

1jjv, resolution 2.00Å

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