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==Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with pre-reactive O-acetyl serine, alpha-aminoacrylate reaction intermediate and peptide inhibitor at the resolution of 2.25A==
==Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with pre-reactive O-acetyl serine, alpha-aminoacrylate reaction intermediate and peptide inhibitor at the resolution of 2.25A==
<StructureSection load='5dbe' size='340' side='right' caption='[[5dbe]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5dbe' size='340' side='right'caption='[[5dbe]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dbe]] is a 2 chain structure. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zu8 4zu8] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4mii 4mii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DBE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DBE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dbe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zu8 4zu8] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4mii 4mii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DBE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene>, <scene name='pdbligand=P1T:2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC+ACID'>P1T</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zu1|4zu1]], [[4zu6|4zu6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JO:2-{[(E)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE]AMINO}PROP-2-ENOIC+ACID'>0JO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dbe OCA], [https://pdbe.org/5dbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dbe RCSB], [https://www.ebi.ac.uk/pdbsum/5dbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dbe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dbe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5dbe RCSB], [http://www.ebi.ac.uk/pdbsum/5dbe PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYSK_HAEIN CYSK_HAEIN]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cysteine synthase]]
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Ekka, M K]]
[[Category: Large Structures]]
[[Category: Kaushik, A]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Kumaran, S]]
[[Category: Ekka MK]]
[[Category: Singh, A K]]
[[Category: Kaushik A]]
[[Category: Amino-acid biosynthesis]]
[[Category: Kumaran S]]
[[Category: Cysteine biosynthesis]]
[[Category: Singh AK]]
[[Category: Pyridoxal phosphate]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor comp]]
[[Category: Transferase-transferase inhibitor complex]]