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==THE STRUCTURE OF THE RACK1 INTERACTION SITES LOCATED WITHIN THE UNIQUE N-TERMINAL REGION OF THE CAMP-SPECIFIC PHOSPHODIESTERASE, PDE4D5.==
 
<StructureSection load='1e9k' size='340' side='right' caption='[[1e9k]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
==The structure of the RACK1 interaction sites located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.==
<StructureSection load='1e9k' size='340' side='right'caption='[[1e9k]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1e9k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E9K FirstGlance]. <br>
<table><tr><td colspan='2'>[[1e9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9K FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9k OCA], [http://pdbe.org/1e9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e9k RCSB], [http://www.ebi.ac.uk/pdbsum/1e9k PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9k OCA], [https://pdbe.org/1e9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9k RCSB], [https://www.ebi.ac.uk/pdbsum/1e9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9k ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.  Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[https://omim.org/entry/614613 614613]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
== Function ==
[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Bolger, G B]]
[[Category: Large Structures]]
[[Category: Houslay, M D]]
[[Category: Bolger GB]]
[[Category: Hyde, E I]]
[[Category: Houslay MD]]
[[Category: Mccahill, A]]
[[Category: Hyde EI]]
[[Category: Smith, K J]]
[[Category: McCahill A]]
[[Category: Steele, M R]]
[[Category: Smith KJ]]
[[Category: Camp-specific phosphodiesterase]]
[[Category: Steele MR]]
[[Category: Hydrolase]]
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