1p45: Difference between revisions
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==Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data== | ==Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data== | ||
<StructureSection load='1p45' size='340' side='right' caption='[[1p45]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='1p45' size='340' side='right'caption='[[1p45]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1p45]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1p45]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P45 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p45 OCA], [https://pdbe.org/1p45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p45 RCSB], [https://www.ebi.ac.uk/pdbsum/1p45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p45 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/1p45_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/1p45_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p45 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 30: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]] | *[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Alland | [[Category: Large Structures]] | ||
[[Category: Fidock | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Gourlie | [[Category: Alland D]] | ||
[[Category: Gregory | [[Category: Fidock DA]] | ||
[[Category: Iwamoto | [[Category: Gourlie BB]] | ||
[[Category: Jacobs | [[Category: Gregory JS]] | ||
[[Category: Janjigian | [[Category: Iwamoto H]] | ||
[[Category: Kreiswirth | [[Category: Jacobs Jr WR]] | ||
[[Category: Kuo | [[Category: Janjigian AD]] | ||
[[Category: Leonard | [[Category: Kreiswirth BN]] | ||
[[Category: Morbidoni | [[Category: Kuo MR]] | ||
[[Category: Musser | [[Category: Leonard M]] | ||
[[Category: Perozzo | [[Category: Morbidoni HR]] | ||
[[Category: Sacchettini | [[Category: Musser JM]] | ||
[[Category: Sneddon | [[Category: Perozzo R]] | ||
[[Category: Staveski | [[Category: Sacchettini JC]] | ||
[[Category: Sneddon SF]] | |||
[[Category: Yee | [[Category: Staveski MM]] | ||
[[Category: Yee C]] | |||
