2j15: Difference between revisions

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==CYCLIC MRIA: AN EXCEPTIONALLY STABLE AND POTENT CYCLIC CONOTOXIN WITH A NOVEL TOPOLOGICAL FOLD THAT TARGETS THE NOREPINEPHRINE TRANSPORTER.==
 
<StructureSection load='2j15' size='340' side='right' caption='[[2j15]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
==Cyclic MrIA: An exceptionally stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter.==
<StructureSection load='2j15' size='340' side='right'caption='[[2j15]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j15]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J15 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j15]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_marmoreus Conus marmoreus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J15 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 21 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j15 OCA], [http://pdbe.org/2j15 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j15 RCSB], [http://www.ebi.ac.uk/pdbsum/2j15 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j15 OCA], [https://pdbe.org/2j15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j15 RCSB], [https://www.ebi.ac.uk/pdbsum/2j15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j15 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CT1A_CONMR CT1A_CONMR]] Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2).<ref>PMID:11528421</ref> <ref>PMID:12837768</ref> <ref>PMID:12885787</ref> <ref>PMID:16154696</ref>
[https://www.uniprot.org/uniprot/CTA1A_CONMR CTA1A_CONMR] Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2) (PubMed:11528421, PubMed:12837768, PubMed:12885787, PubMed:16154696). Activity has been described on both human (inhibition of norepinephrine uptake is IC(50)=1.26 uM) and rat (pIC(50)=6.21 corresponding IC(50)=0.16 uM) transporters (PubMed:11528421, PubMed:12885787). Acts as a reversible non-competitive inhibitor (PubMed:11528421).<ref>PMID:11528421</ref> <ref>PMID:12837768</ref> <ref>PMID:12885787</ref> <ref>PMID:16154696</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alewood, P F]]
[[Category: Conus marmoreus]]
[[Category: Armishaw, C J]]
[[Category: Large Structures]]
[[Category: Colgrave, M L]]
[[Category: Alewood PF]]
[[Category: Craik, D J]]
[[Category: Armishaw CJ]]
[[Category: Daly, N L]]
[[Category: Colgrave ML]]
[[Category: Lovelace, E S]]
[[Category: Craik DJ]]
[[Category: Walstrom, M E]]
[[Category: Daly NL]]
[[Category: Toxin]]
[[Category: Lovelace ES]]
[[Category: Walstrom ME]]
Retrieved from "https://proteopedia.org/2j15"