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==Solution NMR Structure of human protein HSPCO34. Northeast Structural Genomics Target HR1958==
==Solution NMR Structure of human protein HSPCO34. Northeast Structural Genomics Target HR1958==
<StructureSection load='1xpw' size='340' side='right' caption='[[1xpw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1xpw' size='340' side='right'caption='[[1xpw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xpw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XPW FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPW FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tvg|1tvg]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PP25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpw OCA], [https://pdbe.org/1xpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpw RCSB], [https://www.ebi.ac.uk/pdbsum/1xpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpw ProSAT], [https://www.topsan.org/Proteins/NESGC/1xpw TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpw OCA], [http://pdbe.org/1xpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xpw RCSB], [http://www.ebi.ac.uk/pdbsum/1xpw PDBsum], [http://www.topsan.org/Proteins/NESGC/1xpw TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IFT25_HUMAN IFT25_HUMAN]] Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).  
[https://www.uniprot.org/uniprot/IFT25_HUMAN IFT25_HUMAN] Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpw_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpw_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Acton, T B]]
[[Category: Large Structures]]
[[Category: Kennedy, M A]]
[[Category: Acton TB]]
[[Category: Ma, L C]]
[[Category: Kennedy MA]]
[[Category: Montelione, G T]]
[[Category: Ma LC]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Ramelot, T A]]
[[Category: Ramelot TA]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Apc10-related protein]]
[[Category: Beta-sandwich]]
[[Category: C1orf41]]
[[Category: Gene pp25]]
[[Category: Homo sapien]]
[[Category: Jellyroll]]
[[Category: Locus loc51668]]
[[Category: Nesgc cluster id 3237]]
[[Category: PSI, Protein structure initiative]]
[[Category: Target hr1958]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/1xpw"