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==LYQLEN peptide derived from human insulin chain A, residues 13-18==
==LYQLEN peptide derived from human insulin chain A, residues 13-18==
<StructureSection load='2omp' size='340' side='right' caption='[[2omp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2omp' size='340' side='right'caption='[[2omp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2omp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OMP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2omp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OMP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2omp OCA], [http://pdbe.org/2omp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2omp RCSB], [http://www.ebi.ac.uk/pdbsum/2omp PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2omp OCA], [https://pdbe.org/2omp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2omp RCSB], [https://www.ebi.ac.uk/pdbsum/2omp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2omp ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.,Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747<ref>PMID:17468747</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2omp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eisenberg, D]]
[[Category: Large Structures]]
[[Category: Ivanova, M I]]
[[Category: Eisenberg D]]
[[Category: Sawaya, M R]]
[[Category: Ivanova MI]]
[[Category: Antiparallel beta-sheet]]
[[Category: Sawaya MR]]
[[Category: Protein fibril]]
[[Category: Steric zipper]]

Latest revision as of 06:29, 3 April 2024

LYQLEN peptide derived from human insulin chain A, residues 13-18

2omp, resolution 1.90Å

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