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==SOLUTION STRUCTURE AND DNA BINDING OF THE EFFECTOR DOMAIN FROM THE GLOBAL REGULATOR PRRA(REGA) FROM R. SPHAEROIDES: INSIGHTS INTO DNA BINDING SPECIFICITY==
 
<StructureSection load='1umq' size='340' side='right' caption='[[1umq]], [[NMR_Ensembles_of_Models | 5 NMR models]]' scene=''>
==solution structure and DNA binding of the effector domain from the global regulator PrrA(RegA) from R. sphaeroides: Insights into DNA binding specificity==
<StructureSection load='1umq' size='340' side='right'caption='[[1umq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1umq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UMQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1umq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UMQ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1umq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1umq OCA], [http://pdbe.org/1umq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1umq RCSB], [http://www.ebi.ac.uk/pdbsum/1umq PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1umq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1umq OCA], [https://pdbe.org/1umq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1umq RCSB], [https://www.ebi.ac.uk/pdbsum/1umq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1umq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REGA_CERS4 REGA_CERS4] Member of the two-component regulatory system RegB/RegA. Involved in transactivating anaerobic expression of the photosynthetic apparatus. It is a transcriptional regulator that is responsible for activating expression of the puf, puh, and puc operons in response to a decrease in oxygen tension.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/um/1umq_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/um/1umq_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1umq ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[Response regulator|Response regulator]]
*[[Response regulator 3D structure|Response regulator 3D structure]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rhodococcus capsulatus molisch 1907]]
[[Category: Cereibacter sphaeroides]]
[[Category: Laguri, C]]
[[Category: Large Structures]]
[[Category: Phillips-Jones, M K]]
[[Category: Laguri C]]
[[Category: Williamson, M P]]
[[Category: Phillips-Jones MK]]
[[Category: Activator]]
[[Category: Williamson MP]]
[[Category: Dna binding domain]]
[[Category: Dna-binding]]
[[Category: Dna-binding protein]]
[[Category: Helix-turn-helix]]
[[Category: Phosphorylation]]
[[Category: Response regulator]]
[[Category: Sensory transduction]]
[[Category: Transcription regulation]]
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