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[[Image:2dwc.jpg|left|200px]]


{{Structure
==Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP==
|PDB= 2dwc |SIZE=350|CAPTION= <scene name='initialview01'>2dwc</scene>, resolution 1.70&Aring;
<StructureSection load='2dwc' size='340' side='right'caption='[[2dwc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
<table><tr><td colspan='2'>[[2dwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWC FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
|GENE= PH0318 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwc OCA], [https://pdbe.org/2dwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwc RCSB], [https://www.ebi.ac.uk/pdbsum/2dwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwc ProSAT], [https://www.topsan.org/Proteins/RSGI/2dwc TOPSAN]</span></td></tr>
 
</table>
'''Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP'''
== Function ==
 
[https://www.uniprot.org/uniprot/PURT_PYRHO PURT_PYRHO] Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP.[HAMAP-Rule:MF_01643]
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2DWC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWC OCA].  
Check<jmol>
[[Category: Pyrococcus horikoshii]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwc_consurf.spt"</scriptWhenChecked>
[[Category: Arai, R.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Kamo-Uchikubo, T.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
  </jmolCheckbox>
[[Category: Shirouzu, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwc ConSurf].
[[Category: Yokoyama, S.]]
<div style="clear:both"></div>
[[Category: Yoshikawa, S.]]
__TOC__
[[Category: ADP]]
</StructureSection>
[[Category: SO4]]
[[Category: Large Structures]]
[[Category: national project on protein structural and functional analyse]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: nppsfa]]
[[Category: Arai R]]
[[Category: phosphoribosylglycinamide formyltransferase]]
[[Category: Kamo-Uchikubo T]]
[[Category: purine ribonucleotide biosynthesis]]
[[Category: Shirouzu M]]
[[Category: purt]]
[[Category: Yokoyama S]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: Yoshikawa S]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:58:06 2008''

Latest revision as of 08:31, 25 October 2023

Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP

2dwc, resolution 1.70Å

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