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==STRUCTURAL EFFECTS OF MONOVALENT ANIONS ON POLYMORPHIC LYSOZYME CRYSTALS==
==STRUCTURAL EFFECTS OF MONOVALENT ANIONS ON POLYMORPHIC LYSOZYME CRYSTALS==
<StructureSection load='1hf4' size='340' side='right' caption='[[1hf4]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='1hf4' size='340' side='right'caption='[[1hf4]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1hf4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HF4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1hf4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HF4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[193l|193l]], [[194l|194l]], [[1a2y|1a2y]], [[1aki|1aki]], [[1at5|1at5]], [[1at6|1at6]], [[1azf|1azf]], [[1b0d|1b0d]], [[1b2k|1b2k]], [[1bgi|1bgi]], [[1bhz|1bhz]], [[1bvk|1bvk]], [[1bvx|1bvx]], [[1bwh|1bwh]], [[1bwi|1bwi]], [[1bwj|1bwj]], [[1c08|1c08]], [[1c10|1c10]], [[1dpw|1dpw]], [[1dpx|1dpx]], [[1dqj|1dqj]], [[1e8l|1e8l]], [[1f0w|1f0w]], [[1f10|1f10]], [[1f3j|1f3j]], [[1flq|1flq]], [[1flu|1flu]], [[1flw|1flw]], [[1fly|1fly]], [[1fn5|1fn5]], [[1hsw|1hsw]], [[1hsx|1hsx]], [[1jpo|1jpo]], [[1kip|1kip]], [[1kiq|1kiq]], [[1kir|1kir]], [[1kxw|1kxw]], [[1kxx|1kxx]], [[1kxy|1kxy]], [[1lcn|1lcn]], [[1lkr|1lkr]], [[1lks|1lks]], [[1lpi|1lpi]], [[1lyo|1lyo]], [[1lz8|1lz8]], [[1lzn|1lzn]], [[1mel|1mel]], [[1qtk|1qtk]], [[1rfp|1rfp]], [[1uco|1uco]], [[1uia|1uia]], [[1uib|1uib]], [[1uic|1uic]], [[1uid|1uid]], [[1uie|1uie]], [[1uif|1uif]], [[1uig|1uig]], [[1uih|1uih]], [[1xei|1xei]], [[1xej|1xej]], [[1xek|1xek]], [[2lyo|2lyo]], [[3lyo|3lyo]], [[3lzt|3lzt]], [[4lyo|4lyo]], [[4lzt|4lzt]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf4 OCA], [https://pdbe.org/1hf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hf4 RCSB], [https://www.ebi.ac.uk/pdbsum/1hf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hf4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hf4 OCA], [http://pdbe.org/1hf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hf4 RCSB], [http://www.ebi.ac.uk/pdbsum/1hf4 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hf4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hf4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hf4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Lysozyme]]
[[Category: Large Structures]]
[[Category: Broutin, I]]
[[Category: Broutin I]]
[[Category: Ducruix, A]]
[[Category: Ducruix A]]
[[Category: Ries-Kautt, M]]
[[Category: Ries-Kautt M]]
[[Category: Vaney, M C]]
[[Category: Vaney MC]]
[[Category: Hydrolase]]

Latest revision as of 08:30, 6 November 2024

STRUCTURAL EFFECTS OF MONOVALENT ANIONS ON POLYMORPHIC LYSOZYME CRYSTALS

1hf4, resolution 1.45Å

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