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[[Image:2g3y.gif|left|200px]]


{{Structure
==Crystal structure of the human small GTPase GEM==
|PDB= 2g3y |SIZE=350|CAPTION= <scene name='initialview01'>2g3y</scene>, resolution 2.40&Aring;
<StructureSection load='2g3y' size='340' side='right'caption='[[2g3y]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
<table><tr><td colspan='2'>[[2g3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3Y FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= GEM, KIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3y OCA], [https://pdbe.org/2g3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3y RCSB], [https://www.ebi.ac.uk/pdbsum/2g3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GEM_HUMAN GEM_HUMAN] Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g3y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g3y ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the human small GTPase GEM'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
__TOC__
==Disease==
</StructureSection>
Known diseases associated with this structure: Long QT syndrome-7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600681 600681]], Short QT syndrome-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600681 600681]]
 
==About this Structure==
2G3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3Y OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berridge, G.]]
[[Category: Berridge G]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Fedorov O]]
[[Category: Fedorov, O.]]
[[Category: Gileadi C]]
[[Category: Gileadi, C.]]
[[Category: Lee WH]]
[[Category: Lee, W H.]]
[[Category: Pantic N]]
[[Category: Pantic, N.]]
[[Category: Schoch G]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sobott F]]
[[Category: Schoch, G.]]
[[Category: Soundararajan M]]
[[Category: Sobott, F.]]
[[Category: Sundstrom M]]
[[Category: Soundararajan, M.]]
[[Category: Turnbull A]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu E]]
[[Category: Turnbull, A.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: GDP]]
[[Category: gdp]]
[[Category: gem]]
[[Category: inactive state]]
[[Category: rgk family]]
[[Category: sgc]]
[[Category: small gtpase]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:08:50 2008''

Latest revision as of 09:35, 30 August 2023

Crystal structure of the human small GTPase GEM

2g3y, resolution 2.40Å

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