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==Monomeric structure of the active catalytic domain of complement protease C1r==
==Monomeric structure of the active catalytic domain of complement protease C1r==
<StructureSection load='1md8' size='340' side='right' caption='[[1md8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1md8' size='340' side='right'caption='[[1md8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1md8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MD8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1md8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MD8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gpz|1gpz]], [[1md7|1md7]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1md8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1md8 OCA], [https://pdbe.org/1md8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1md8 RCSB], [https://www.ebi.ac.uk/pdbsum/1md8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1md8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1md8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1md8 OCA], [http://pdbe.org/1md8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1md8 RCSB], [http://www.ebi.ac.uk/pdbsum/1md8 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN]] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.  
[https://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1md8_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1md8_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1md8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Complement subcomponent C1r]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arlaud, G J]]
[[Category: Arlaud GJ]]
[[Category: Budayova-Spano, M]]
[[Category: Budayova-Spano M]]
[[Category: Fontecilla-Camps, J]]
[[Category: Fontecilla-Camps J]]
[[Category: Gaboriaud, C]]
[[Category: Gaboriaud C]]
[[Category: Grabarse, W]]
[[Category: Grabarse W]]
[[Category: Hillen, H]]
[[Category: Hillen H]]
[[Category: Lacroix, M]]
[[Category: Lacroix M]]
[[Category: Schmidt, M]]
[[Category: Schmidt M]]
[[Category: Thielens, N M]]
[[Category: Thielens NM]]
[[Category: Activation]]
[[Category: Complement]]
[[Category: Hydrolase]]
[[Category: Innate immunity]]
[[Category: Serine protease]]
[[Category: Substrate specificity]]
Retrieved from "https://proteopedia.org/1md8"