2ius: Difference between revisions

 

==E. coli FtsK motor domain==

<StructureSection load='2ius' size='340' side='right'caption='[[2ius]], [[Resolution|resolution]] 2.70&Aring;' scene=''>

<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUS FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [https://pdbe.org/2ius PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [https://www.ebi.ac.uk/pdbsum/2ius PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FTSK_ECOLI FTSK_ECOLI] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum.<ref>PMID:9829960</ref> <ref>PMID:9723913</ref> <ref>PMID:11703663</ref> <ref>PMID:11832210</ref> <ref>PMID:15522074</ref> <ref>PMID:16553881</ref> <ref>PMID:18363794</ref> <ref>PMID:19246541</ref> <ref>PMID:19854947</ref> <ref>PMID:20081205</ref> <ref>PMID:21371996</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/2ius_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ius ConSurf].

[[Category: Escherichia coli]]

[[Category: Large Structures]]

[[Category: Lowe J]]

[[Category: Massey TH]]

[[Category: Mercogliano CP]]

[[Category: Sherratt DJ]]

[[Category: Yates J]]