2j1l: Difference between revisions

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[[Image:2j1l.gif|left|200px]]


{{Structure
==Crystal Structure of Human Rho-related GTP-binding protein RhoD==
|PDB= 2j1l |SIZE=350|CAPTION= <scene name='initialview01'>2j1l</scene>, resolution 2.50&Aring;
<StructureSection load='2j1l' size='340' side='right'caption='[[2j1l]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
<table><tr><td colspan='2'>[[2j1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J1L FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1l OCA], [https://pdbe.org/2j1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j1l RCSB], [https://www.ebi.ac.uk/pdbsum/2j1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHOD_HUMAN RHOD_HUMAN] Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.<ref>PMID:23087206</ref> <ref>PMID:23454120</ref> <ref>PMID:24102721</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j1l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j1l ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
==About this Structure==
== References ==
2J1L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1L OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Small monomeric GTPase]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Bray J]]
[[Category: Bray, J.]]
[[Category: Doyle D]]
[[Category: Delft, F Von.]]
[[Category: Edwards A]]
[[Category: Doyle, D.]]
[[Category: Elkins J]]
[[Category: Edwards, A.]]
[[Category: Gileadi C]]
[[Category: Elkins, J.]]
[[Category: Gorrec F]]
[[Category: Gileadi, C.]]
[[Category: Johansson C]]
[[Category: Gorrec, F.]]
[[Category: Niesen FH]]
[[Category: Johansson, C.]]
[[Category: Pike ACW]]
[[Category: Niesen, F H.]]
[[Category: Schoch G]]
[[Category: Pike, A C.W.]]
[[Category: Smee C]]
[[Category: Schoch, G.]]
[[Category: Sobott F]]
[[Category: Smee, C.]]
[[Category: Sundstrom M]]
[[Category: Sobott, F.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Watt S]]
[[Category: Turnbull, A P.]]
[[Category: Weigelt J]]
[[Category: Watt, S.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: GDP]]
[[Category: MG]]
[[Category: endosome dynamic]]
[[Category: gtp-binding]]
[[Category: gtpase]]
[[Category: hydrolase]]
[[Category: lipoprotein]]
[[Category: membrane]]
[[Category: methylation]]
[[Category: nucleotide-binding]]
[[Category: prenylation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:23:46 2008''
Retrieved from "https://proteopedia.org/2j1l"