2mf2: Difference between revisions

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==Structural and biophysical characterization of the mRNA interferase SaMazF from Staphylococcus aureus.==
==Structural and biophysical characterization of the mRNA interferase SaMazF from Staphylococcus aureus.==
<StructureSection load='2mf2' size='340' side='right' caption='[[2mf2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mf2' size='340' side='right'caption='[[2mf2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mf2]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MF2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mf2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MF2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mzm|4mzm]], [[4mzt|4mzt]], [[4mzp|4mzp]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mf2 OCA], [http://pdbe.org/2mf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2mf2 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mf2 OCA], [https://pdbe.org/2mf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mf2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mf2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MAZF_STAAW MAZF_STAAW]] Toxic component of a toxin-antitoxin (TA) module. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. Cleavages occur preferentially in a U-rich region with a consensus sequence of 5'-[ACG]UU[ACG]-3' in single-stranded RNA (By similarity).  
[https://www.uniprot.org/uniprot/MAZF_STAA8 MAZF_STAA8] Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE.[UniProtKB:A6QIR4]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cheung, A]]
[[Category: Large Structures]]
[[Category: Loris, R]]
[[Category: Staphylococcus aureus]]
[[Category: Nuland, N A.J van]]
[[Category: Cheung A]]
[[Category: Zorzini, V]]
[[Category: Loris R]]
[[Category: Ccdb/mazf fold]]
[[Category: Zorzini V]]
[[Category: Hydrolase]]
[[Category: Van Nuland NAJ]]
[[Category: Ribonuclease]]