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==Structure of a two-G-tetrad basket-type intramolecular G-quadruplex formed by human telomeric repeats in K+ solution==
==Structure of a two-G-tetrad basket-type intramolecular G-quadruplex formed by human telomeric repeats in K+ solution==
<StructureSection load='2kf8' size='340' side='right' caption='[[2kf8]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2kf8' size='340' side='right'caption='[[2kf8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kf8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KF8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kf8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KF8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[1k8p|1k8p]], [[2gku|2gku]], [[2aqy|2aqy]], [[2jsk|2jsk]], [[2jsl|2jsl]], [[2jsm|2jsm]], [[2jsq|2jsq]], [[2kf7|2kf7]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kf8 OCA], [http://pdbe.org/2kf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kf8 RCSB], [http://www.ebi.ac.uk/pdbsum/2kf8 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kf8 OCA], [https://pdbe.org/2kf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kf8 RCSB], [https://www.ebi.ac.uk/pdbsum/2kf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kf8 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Previously, it has been reported that human telomeric DNA sequences could adopt in different experimental conditions four different intramolecular G-quadruplexes each involving three G-tetrad layers, namely, Na(+) solution antiparallel-stranded basket form, K(+) crystal parallel-stranded propeller form, K(+) solution (3 + 1) Form 1, and K(+) solution (3 + 1) Form 2. Here we present a new intramolecular G-quadruplex adopted by a four-repeat human telomeric sequence in K(+) solution (Form 3). This structure is a basket-type G-quadruplex with only two G-tetrad layers: loops are successively edgewise, diagonal, and edgewise; glycosidic conformations of guanines are syn*syn*anti*anti around each tetrad. Each strand of the core has both a parallel and an antiparallel adjacent strands; there are one narrow, one wide, and two medium grooves. Despite the presence of only two G-tetrads in the core, this structure is more stable than the three-G-tetrad intramolecular G-quadruplexes previously observed for human telomeric sequences in K(+) solution. Detailed structural elucidation of Form 3 revealed extensive base pairing and stacking in the loops capping both ends of the G-tetrad core, which might explain the high stability of the structure. This novel structure highlights the conformational heterogeneity of human telomeric DNA. It establishes a new folding principle for G-quadruplexes and suggests new loop sequences and structures for targeting in human telomeric DNA.
Structure of the Human Telomere in K(+) Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers.,Lim KW, Amrane S, Bouaziz S, Xu W, Mu Y, Patel DJ, Luu KN, Phan AT J Am Chem Soc. 2009 Mar 9. PMID:19271707<ref>PMID:19271707</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kf8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Amrane, S]]
[[Category: Large Structures]]
[[Category: Bouaziz, S]]
[[Category: Amrane S]]
[[Category: Lim, K W]]
[[Category: Bouaziz S]]
[[Category: Luu, K N]]
[[Category: Lim KW]]
[[Category: Mu, Y]]
[[Category: Luu KN]]
[[Category: Patel, D J]]
[[Category: Mu Y]]
[[Category: Phan, A T]]
[[Category: Patel DJ]]
[[Category: Xu, W]]
[[Category: Phan AT]]
[[Category: Anticancer target]]
[[Category: Xu W]]
[[Category: Dna]]
[[Category: Human telomere]]
[[Category: Intramolecular g-quadruplex]]
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