2q3g: Difference between revisions
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==Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin== | ==Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin== | ||
<StructureSection load='2q3g' size='340' side='right' caption='[[2q3g]], [[Resolution|resolution]] 1.11Å' scene=''> | <StructureSection load='2q3g' size='340' side='right'caption='[[2q3g]], [[Resolution|resolution]] 1.11Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2q3g]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2q3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3G FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.11Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3g OCA], [https://pdbe.org/2q3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3g RCSB], [https://www.ebi.ac.uk/pdbsum/2q3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3g ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PDLI7_HUMAN PDLI7_HUMAN] May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity).<ref>PMID:7929196</ref> <ref>PMID:11874232</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3g_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3g_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3g ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| Line 27: | Line 27: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bunkoczi | [[Category: Arrowsmith CH]] | ||
[[Category: Burgess-Brown | [[Category: Bunkoczi G]] | ||
[[Category: Burgess-Brown N]] | |||
[[Category: Doyle | [[Category: Doyle DA]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Elkins | [[Category: Elkins J]] | ||
[[Category: Gileadi | [[Category: Gileadi C]] | ||
[[Category: Gileadi | [[Category: Gileadi O]] | ||
[[Category: Papagrigoriou | [[Category: Papagrigoriou E]] | ||
[[Category: Pike | [[Category: Pike ACW]] | ||
[[Category: Salah E]] | |||
[[Category: Salah | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Umeano C]] | ||
[[Category: Umeano | [[Category: Uppenberg J]] | ||
[[Category: Uppenberg | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 09:14, 21 February 2024
Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin
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