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[[Image:3bgg.jpg|left|200px]]


{{Structure
==Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP==
|PDB= 3bgg |SIZE=350|CAPTION= <scene name='initialview01'>3bgg</scene>, resolution 1.93&Aring;
<StructureSection load='3bgg' size='340' side='right'caption='[[3bgg]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BMP:6-HYDROXYURIDINE-5&#39;-PHOSPHATE'>BMP</scene>
<table><tr><td colspan='2'>[[3bgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGG FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
|GENE= UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgg OCA], [https://pdbe.org/3bgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgg RCSB], [https://www.ebi.ac.uk/pdbsum/3bgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
== Function ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgg ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Human Orotidine 5'-monophosphate Decarboxylase complexed with BMP'''
==See Also==
 
*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
 
== References ==
==About this Structure==
<references/>
3BGG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGG OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Kotra LP]]
[[Category: Kotra, L P.]]
[[Category: Liu Y]]
[[Category: Liu, Y.]]
[[Category: Pai EF]]
[[Category: Pai, E F.]]
[[Category: Tang HL]]
[[Category: Tang, H L.]]
[[Category: Wang XY]]
[[Category: Wang, X Y.]]
[[Category: BMP]]
[[Category: alternative splicing]]
[[Category: bmp]]
[[Category: c-terminal domain]]
[[Category: disease mutation]]
[[Category: glycosyltransferase]]
[[Category: human]]
[[Category: lyase]]
[[Category: multifunctional enzyme]]
[[Category: orotidine 5'-monophosphate decarboxylase]]
[[Category: polymorphism]]
[[Category: pyrimidine biosynthesis]]
[[Category: transferase]]
[[Category: ump synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:59:29 2008''
Retrieved from "https://proteopedia.org/3bgg"