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==CONFORMATIONAL STUDIES ON SRTB, A NON-SELECTIVE ENDOTHELIN RECEPTOR AGONIST, AND ON IRL 1620, AN ETB RECEPTOR SPECIFIC AGONIST==
==CONFORMATIONAL STUDIES ON SRTB, A NON-SELECTIVE ENDOTHELIN RECEPTOR AGONIST, AND ON IRL 1620, AN ETB RECEPTOR SPECIFIC AGONIST==
<StructureSection load='1srb' size='340' side='right' caption='[[1srb]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1srb' size='340' side='right'caption='[[1srb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1srb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atren Atren]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SRB FirstGlance]. <br>
<table><tr><td colspan='2'>[[1srb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atractaspis_andersonii Atractaspis andersonii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SRB FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1srb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1srb OCA], [http://pdbe.org/1srb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1srb RCSB], [http://www.ebi.ac.uk/pdbsum/1srb PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1srb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1srb OCA], [https://pdbe.org/1srb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1srb RCSB], [https://www.ebi.ac.uk/pdbsum/1srb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1srb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SRTX_ATREN SRTX_ATREN]] Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.<ref>PMID:21889567</ref>  Sarafotoxin-B: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays high agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the picomolar range) and endothelin-1 receptor (EDNRA) (lower affinities) (PubMed:21889567).<ref>PMID:21889567</ref>
[https://www.uniprot.org/uniprot/SRTX_ATREN SRTX_ATREN] Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.<ref>PMID:21889567</ref>  Sarafotoxin-B: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays high agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the picomolar range) and endothelin-1 receptor (EDNRA) (lower affinities) (PubMed:21889567).<ref>PMID:21889567</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atren]]
[[Category: Atractaspis andersonii]]
[[Category: Atkins, A R]]
[[Category: Large Structures]]
[[Category: Smith, R]]
[[Category: Atkins AR]]
[[Category: Toxin]]
[[Category: Smith R]]
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