1m0g

Solution structure of the alpha domain of mt_nc

spinqualitylabelsall models 1m0g Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1m0g is a 1 chain structure with sequence from Notothenia coriiceps. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: CD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MTA_NOTNE Metallothioneins have a high content of cysteine residues that bind various heavy metals. Publication Abstract from PubMed The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins. Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps.,Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA Structure. 2003 Apr;11(4):435-43. PMID:12679021 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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