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==NMR structure of the lambda 5 22-45 peptide==
==NMR structure of the lambda 5 22-45 peptide==
<StructureSection load='2lkq' size='340' side='right' caption='[[2lkq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lkq' size='340' side='right'caption='[[2lkq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lkq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LKQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKQ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkq OCA], [http://pdbe.org/2lkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lkq RCSB], [http://www.ebi.ac.uk/pdbsum/2lkq PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lkq OCA], [https://pdbe.org/2lkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lkq RCSB], [https://www.ebi.ac.uk/pdbsum/2lkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lkq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/IGLL1_HUMAN IGLL1_HUMAN]] Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2) [MIM:[http://omim.org/entry/613500 613500]]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.  
[https://www.uniprot.org/uniprot/IGLL1_HUMAN IGLL1_HUMAN] Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2) [MIM:[https://omim.org/entry/613500 613500]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IGLL1_HUMAN IGLL1_HUMAN]] Critical for B-cell development.<ref>PMID:9419212</ref>
[https://www.uniprot.org/uniprot/IGLL1_HUMAN IGLL1_HUMAN] Critical for B-cell development.<ref>PMID:9419212</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Boned, A]]
[[Category: Homo sapiens]]
[[Category: Bornet, O]]
[[Category: Large Structures]]
[[Category: Breton, C]]
[[Category: Boned A]]
[[Category: Elantak, L]]
[[Category: Bornet O]]
[[Category: Espeli, M]]
[[Category: Breton C]]
[[Category: Feracci, M]]
[[Category: Elantak L]]
[[Category: Guerlesquin, F]]
[[Category: Espeli M]]
[[Category: Roche, P]]
[[Category: Feracci M]]
[[Category: Schiff, C]]
[[Category: Guerlesquin F]]
[[Category: B cell development]]
[[Category: Roche P]]
[[Category: Immune system]]
[[Category: Schiff C]]
[[Category: Pre-bcr]]
Retrieved from "https://proteopedia.org/2lkq"