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==NMR Structure of GzCVNH (Gibberella zeae CVNH)==
==NMR Structure of GzCVNH (Gibberella zeae CVNH)==
<StructureSection load='2l2f' size='340' side='right' caption='[[2l2f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l2f' size='340' side='right'caption='[[2l2f]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2F FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2F FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2f OCA], [http://pdbe.org/2l2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l2f RCSB], [http://www.ebi.ac.uk/pdbsum/2l2f PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2f OCA], [https://pdbe.org/2l2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2f RCSB], [https://www.ebi.ac.uk/pdbsum/2l2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2f ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/I1RM03_GIBZE I1RM03_GIBZE]
Members of the cyanovirin-N homolog (CVNH) lectin family are found in bacteria, fungi and plants. As part of our ongoing work on CVNH structure-function studies, we determined the high-resolution NMR solution structure of the homolog from the wheat head blight disease causing ascomycetous fungus Gibberella zeae (or Fusarium graminearum), hereafter called GzCVNH. Like cyanovirin-N (CV-N), GzCVNH comprises two tandem sequence repeats and the protein sequence exhibits 30% identity with CV-N. The overall structure is similar to those of other members of the CVNH family, with the conserved pseudo-symmetric halves of the structure, domains A and B, closely resembling recently determined structures of Tuber borchii, Neurospora crassa, and Ceratopteris richardii CVNH proteins. Although GzCVNH exhibits a similar glycan recognition profile to CV-N and specifically binds to Manalpha(1-2)Manalpha, its weak carbohydrate binding affinity to only one binding site is insufficient for conferring anti-HIV activity. Proteins 2011; (c) 2011 Wiley-Liss, Inc.
 
NMR solution structure of a cyanovirin homolog from wheat head blight fungus.,Matei E, Louis JM, Jee J, Gronenborn AM Proteins. 2011 Jan 18. doi: 10.1002/prot.22981. PMID:21365681<ref>PMID:21365681</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2l2f" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fusarium graminearum]]
[[Category: Fusarium graminearum]]
[[Category: Gronenborn, A M]]
[[Category: Large Structures]]
[[Category: Jee, J G]]
[[Category: Gronenborn AM]]
[[Category: Louis, J M]]
[[Category: Jee JG]]
[[Category: Matei, E]]
[[Category: Louis JM]]
[[Category: Carbohydrate binding protein]]
[[Category: Matei E]]
[[Category: Cyanovirin-n homolog]]
[[Category: Lectin]]
[[Category: Sugar binding protein]]

Latest revision as of 06:51, 1 May 2024

NMR Structure of GzCVNH (Gibberella zeae CVNH)

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