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==Solution structure of the homeobox domain of Zinc finger homeobox protein 1b (Smad interacting protein 1)==
==Solution structure of the homeobox domain of Zinc finger homeobox protein 1b (Smad interacting protein 1)==
<StructureSection load='2da7' size='340' side='right' caption='[[2da7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2da7' size='340' side='right'caption='[[2da7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2da7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DA7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2da7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DA7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZFHX1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2da7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2da7 OCA], [http://pdbe.org/2da7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2da7 RCSB], [http://www.ebi.ac.uk/pdbsum/2da7 PDBsum], [http://www.topsan.org/Proteins/RSGI/2da7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2da7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2da7 OCA], [https://pdbe.org/2da7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2da7 RCSB], [https://www.ebi.ac.uk/pdbsum/2da7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2da7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2da7 TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ZEB2_HUMAN ZEB2_HUMAN] Mowat-Wilson syndrome due to monosomy 2q22;Mowat-Wilson syndrome due to a ZEB2 point mutation. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ZEB2_HUMAN ZEB2_HUMAN] Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212).<ref>PMID:16061479</ref> <ref>PMID:20516212</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2da7_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2da7_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2da7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Inoue, M]]
[[Category: Large Structures]]
[[Category: Kigawa, T]]
[[Category: Inoue M]]
[[Category: Koshiba, S]]
[[Category: Kigawa T]]
[[Category: Ohnishi, S]]
[[Category: Koshiba S]]
[[Category: Structural genomic]]
[[Category: Ohnishi S]]
[[Category: Sato, M]]
[[Category: Sato M]]
[[Category: Yokoyama, S]]
[[Category: Yokoyama S]]
[[Category: Dna binding protein]]
[[Category: Homeobox domain]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Three helices with the dna binding helix-turn-helix motif]]
Retrieved from "https://proteopedia.org/2da7"