2mh3: Difference between revisions

<StructureSection load='2mh3' size='340' side='right'caption='[[2mh3]]' scene=''>

<table><tr><td colspan='2'>[[2mh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MH3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh3 OCA], [https://pdbe.org/2mh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mh3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Boelens R]]

[[Category: Coglievina M]]

[[Category: Pintar A]]

[[Category: Pongor S]]

[[Category: Popovic M]]

[[Category: Wienk H]]