2l9j: Difference between revisions

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==hRSV M2-1 core domain structure==
==hRSV M2-1 core domain structure==
<StructureSection load='2l9j' size='340' side='right' caption='[[2l9j]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l9j' size='340' side='right'caption='[[2l9j]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l9j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L9J FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9J FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9j OCA], [http://pdbe.org/2l9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l9j RCSB], [http://www.ebi.ac.uk/pdbsum/2l9j PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9j OCA], [https://pdbe.org/2l9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9j RCSB], [https://www.ebi.ac.uk/pdbsum/2l9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hrsv]]
[[Category: Human orthopneumovirus]]
[[Category: Blondot, M]]
[[Category: Large Structures]]
[[Category: Bontems, F]]
[[Category: Blondot M]]
[[Category: Dubosclard, V]]
[[Category: Bontems F]]
[[Category: Eleouet, J]]
[[Category: Dubosclard V]]
[[Category: Sizun, C]]
[[Category: Eleouet J]]
[[Category: Processivity]]
[[Category: Sizun C]]
[[Category: Rna binding protein]]
[[Category: Transcription]]
[[Category: Transcription co-factor]]
[[Category: Viral protein]]
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