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[[Image:1dfc.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN==
|PDB= 1dfc |SIZE=350|CAPTION= <scene name='initialview01'>1dfc</scene>, resolution 2.90&Aring;
<StructureSection load='1dfc' size='340' side='right'caption='[[1dfc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1dfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DFC FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfc OCA], [https://pdbe.org/1dfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dfc RCSB], [https://www.ebi.ac.uk/pdbsum/1dfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dfc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1dfc TOPSAN]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00257 Fascin]</span>
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dfc OCA], [http://www.ebi.ac.uk/pdbsum/1dfc PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1dfc RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1dfc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dfc ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN'''
==See Also==
 
*[[Fascin|Fascin]]
 
== References ==
==Disease==
<references/>
Known disease associated with this structure: Neuropathy, hereditary sensory and autonomic, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605712 605712]]
__TOC__
 
</StructureSection>
==About this Structure==
1DFC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFC OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Almo, S C.]]
[[Category: Almo SC]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Fedorov, A A.]]
[[Category: Fedorov AA]]
[[Category: Fedorov, E V.]]
[[Category: Fedorov EV]]
[[Category: Matsumura, F.]]
[[Category: Matsumura F]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Ono S]]
[[Category: Ono, S.]]
[[Category: beta-trefoil fold for all four domain]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 05:51:22 2008''

Latest revision as of 06:53, 7 February 2024

CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN

1dfc, resolution 2.90Å

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