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==Crystal structure of an engineered uninhibited Bacillus subtilis xylanase in substrate bound state==
==Crystal structure of an engineered uninhibited Bacillus subtilis xylanase in substrate bound state==
<StructureSection load='2b46' size='340' side='right' caption='[[2b46]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='2b46' size='340' side='right'caption='[[2b46]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b46]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B46 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B46 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.215&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t6e|1t6e]], [[1t6g|1t6g]], [[2b42|2b42]], [[2b45|2b45]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRD_900116:4beta-beta-xylobiose'>PRD_900116</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">xynA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b46 OCA], [https://pdbe.org/2b46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b46 RCSB], [https://www.ebi.ac.uk/pdbsum/2b46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b46 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b46 OCA], [http://pdbe.org/2b46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b46 RCSB], [http://www.ebi.ac.uk/pdbsum/2b46 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/XYNA_BACSU XYNA_BACSU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/2b46_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/2b46_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b46 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus globigii migula 1900]]
[[Category: Bacillus subtilis]]
[[Category: Endo-1,4-beta-xylanase]]
[[Category: Large Structures]]
[[Category: Brijs, K]]
[[Category: Brijs K]]
[[Category: Courtin, C M]]
[[Category: Courtin CM]]
[[Category: Delcour, J A]]
[[Category: De Ranter CJ]]
[[Category: Dewilde, M]]
[[Category: Delcour JA]]
[[Category: Gebruers, K]]
[[Category: Dewilde M]]
[[Category: Rabijns, A]]
[[Category: Gebruers K]]
[[Category: Ranter, C J.De]]
[[Category: Rabijns A]]
[[Category: Sansen, S]]
[[Category: Sansen S]]
[[Category: Sibbesen, O]]
[[Category: Sibbesen O]]
[[Category: Sorensen, J F]]
[[Category: Sorensen JF]]
[[Category: Beta-jelly roll structure]]
[[Category: Hydrolase]]

Latest revision as of 09:15, 14 February 2024

Crystal structure of an engineered uninhibited Bacillus subtilis xylanase in substrate bound state

2b46, resolution 2.21Å

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