2koe: Difference between revisions

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==Human cannabinoid receptor 1 - helix 7/8 peptide==
==Human cannabinoid receptor 1 - helix 7/8 peptide==
<StructureSection load='2koe' size='340' side='right' caption='[[2koe]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
<StructureSection load='2koe' size='340' side='right'caption='[[2koe]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2koe]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2koe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOE FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koe OCA], [http://pdbe.org/2koe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2koe RCSB], [http://www.ebi.ac.uk/pdbsum/2koe PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koe OCA], [https://pdbe.org/2koe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2koe RCSB], [https://www.ebi.ac.uk/pdbsum/2koe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2koe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN]] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>
[https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2koe_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2koe_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2koe ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Deshmukh, L]]
[[Category: Homo sapiens]]
[[Category: Janero, D]]
[[Category: Large Structures]]
[[Category: Makriyannis, A]]
[[Category: Deshmukh L]]
[[Category: Tiburu, E]]
[[Category: Janero D]]
[[Category: Tyukhtenko, S]]
[[Category: Makriyannis A]]
[[Category: Vinogradova, O]]
[[Category: Tiburu E]]
[[Category: Gpcr]]
[[Category: Tyukhtenko S]]
[[Category: Hcb1]]
[[Category: Vinogradova O]]
[[Category: Membrane protein]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/2koe"