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==Crystal structure of shikimate dehydrogenase from aquifex aeolicus at 2.35 angstrom resolution==
==Crystal structure of shikimate dehydrogenase from aquifex aeolicus at 2.35 angstrom resolution==
<StructureSection load='2hk8' size='340' side='right' caption='[[2hk8]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='2hk8' size='340' side='right'caption='[[2hk8]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hk8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HK8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2hk8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HK8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ev9|2ev9]], [[1wxd|1wxd]], [[2hk7|2hk7]], [[2hk9|2hk9]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hk8 OCA], [https://pdbe.org/2hk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hk8 RCSB], [https://www.ebi.ac.uk/pdbsum/2hk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hk8 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_dehydrogenase Shikimate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.25 1.1.1.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hk8 OCA], [http://pdbe.org/2hk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hk8 RCSB], [http://www.ebi.ac.uk/pdbsum/2hk8 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROE_AQUAE AROE_AQUAE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/2hk8_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/2hk8_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hk8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[Shikimate dehydrogenase|Shikimate dehydrogenase]]
*[[Shikimate dehydrogenase 3D structures|Shikimate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aquifex aeolicus huber and stetter 2001]]
[[Category: Aquifex aeolicus]]
[[Category: Shikimate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Andrykovitch, M]]
[[Category: Andrykovitch M]]
[[Category: Gan, J H]]
[[Category: Gan JH]]
[[Category: Gu, Y J]]
[[Category: Gu YJ]]
[[Category: Ji, X]]
[[Category: Ji X]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Liu, H H]]
[[Category: Liu HH]]
[[Category: Prabakaran, P]]
[[Category: Prabakaran P]]
[[Category: Yan, H]]
[[Category: Yan H]]
[[Category: Drug design]]
[[Category: Oxidoreductase]]
[[Category: Shikimate pathway]]

Latest revision as of 09:58, 30 August 2023

Crystal structure of shikimate dehydrogenase from aquifex aeolicus at 2.35 angstrom resolution

2hk8, resolution 2.35Å

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