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==HOLO STRUCTURE OF MALEYL PYRUVATE ISOMERASE, A BACTERIAL GLUTATHIONE-S-TRANSFERASE IN ZETA CLASS==
 
<StructureSection load='2jl4' size='340' side='right' caption='[[2jl4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
==Holo structure of Maleyl Pyruvate Isomerase, a bacterial glutathione- s-transferase in Zeta class==
<StructureSection load='2jl4' size='340' side='right'caption='[[2jl4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jl4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._u2 Pseudomonas sp. u2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JL4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jl4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ralstonia_sp._U2 Ralstonia sp. U2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JL4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v6k|2v6k]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleylacetoacetate_isomerase Maleylacetoacetate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.2 5.2.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jl4 OCA], [https://pdbe.org/2jl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jl4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jl4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jl4 OCA], [http://pdbe.org/2jl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jl4 RCSB], [http://www.ebi.ac.uk/pdbsum/2jl4 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAGL_RALSP NAGL_RALSP] Catalyzes the GSH-dependent isomerization of maleylpyruvate to fumarylpyruvate which is subsequently processed by NagK to form pyruvate and fumarate.<ref>PMID:11133965</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jl4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/2jl4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jl4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
</div>
<div class="pdbe-citations 2jl4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2jl4" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Maleylacetoacetate isomerase]]
[[Category: Large Structures]]
[[Category: Pseudomonas sp. u2]]
[[Category: Ralstonia sp. U2]]
[[Category: Hadfield, A T]]
[[Category: Hadfield AT]]
[[Category: Shoemark, D K]]
[[Category: Shoemark DK]]
[[Category: Williams, P A]]
[[Category: Williams PA]]
[[Category: Zhou, N Y]]
[[Category: Y Zhou N]]
[[Category: Bacterial]]
[[Category: Biodegradation]]
[[Category: Fumaryl pyruvate]]
[[Category: Glutathione-s-transferase]]
[[Category: Gst]]
[[Category: Isomerase]]
[[Category: Maleyl pyruvate]]
[[Category: Pyruvate]]
Retrieved from "https://proteopedia.org/2jl4"