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[[Image:1vqv.gif|left|200px]]


{{Structure
==Crystal Structure of Thiamine Monophosphate Kinase (thil) from Aquifex Aeolicus==
|PDB= 1vqv |SIZE=350|CAPTION= <scene name='initialview01'>1vqv</scene>, resolution 2.65&Aring;
<StructureSection load='1vqv' size='340' side='right'caption='[[1vqv]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[1vqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yaw 1yaw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VQV FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-phosphate_kinase Thiamine-phosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.16 2.7.4.16] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0611 ThiL], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02194 ThiL_N]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqv OCA], [https://pdbe.org/1vqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vqv RCSB], [https://www.ebi.ac.uk/pdbsum/1vqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqv ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1vqv TOPSAN]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqv OCA], [http://www.ebi.ac.uk/pdbsum/1vqv PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1vqv RCSB]</span>
</table>
}}
== Function ==
 
[https://www.uniprot.org/uniprot/THIL_AQUAE THIL_AQUAE] Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.<ref>PMID:18311927</ref>
'''Crystal Structure of Thiamine Monophosphate Kinase (thil) from Aquifex Aeolicus'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
1VQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. This structure supersedes the now removed PDB entry 1YAW. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQV OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/1vqv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vqv ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thiamine-phosphate kinase]]
[[Category: Burley SK]]
[[Category: Burley, S K.]]
[[Category: Eswaramoorthy S]]
[[Category: Eswaramoorthy, S.]]
[[Category: Swaminathan S]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Swaminathan, S.]]
[[Category: dimer]]
[[Category: kinase]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: phosphate]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
[[Category: t1881]]
[[Category: thil]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:10:05 2008''

Latest revision as of 00:05, 28 December 2023

Crystal Structure of Thiamine Monophosphate Kinase (thil) from Aquifex Aeolicus

1vqv, resolution 2.65Å

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