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==Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin==
==Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin==
<StructureSection load='1t5m' size='340' side='right' caption='[[1t5m]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='1t5m' size='340' side='right'caption='[[1t5m]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t5m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T5M FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_filamentosus Streptomyces filamentosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T5M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=DSG:D-ASPARAGINE'>DSG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene>, <scene name='pdbligand=LME:(2S,3R)-2-AZANYL-3-METHYL-PENTANEDIOIC+ACID'>LME</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xt7|1xt7]], [[1t5n|1t5n]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5m OCA], [https://pdbe.org/1t5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t5m RCSB], [https://www.ebi.ac.uk/pdbsum/1t5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t5m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5m OCA], [http://pdbe.org/1t5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t5m RCSB], [http://www.ebi.ac.uk/pdbsum/1t5m PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hancock, R E]]
[[Category: Large Structures]]
[[Category: Jung, D]]
[[Category: Streptomyces filamentosus]]
[[Category: Okon, M]]
[[Category: Hancock RE]]
[[Category: Rozek, A]]
[[Category: Jung D]]
[[Category: Antibiotic]]
[[Category: Okon M]]
[[Category: Calcium-dependent]]
[[Category: Rozek A]]
[[Category: Cubicin]]
[[Category: Daptomycin]]
[[Category: Lipopeptide]]

Latest revision as of 22:13, 26 March 2025

Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin

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