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==Structural and functional analysis of TM XI of the NHE1 isoform of thE NA+/H+ exchanger==
==Structural and functional analysis of TM XI of the NHE1 isoform of thE NA+/H+ exchanger==
<StructureSection load='2kbv' size='340' side='right' caption='[[2kbv]], [[NMR_Ensembles_of_Models | 40 NMR models]]' scene=''>
<StructureSection load='2kbv' size='340' side='right'caption='[[2kbv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kbv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBV FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 40 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbv OCA], [http://pdbe.org/2kbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kbv RCSB], [http://www.ebi.ac.uk/pdbsum/2kbv PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbv OCA], [https://pdbe.org/2kbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbv RCSB], [https://www.ebi.ac.uk/pdbsum/2kbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN]] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>
[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fliegel, L]]
[[Category: Homo sapiens]]
[[Category: Lee, B L]]
[[Category: Large Structures]]
[[Category: Li, X]]
[[Category: Fliegel L]]
[[Category: Liu, Y]]
[[Category: Lee BL]]
[[Category: Sykes, B D]]
[[Category: Li X]]
[[Category: Antiport]]
[[Category: Liu Y]]
[[Category: Glycoprotein]]
[[Category: Sykes BD]]
[[Category: Ion transport]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Micelle]]
[[Category: Nhe1]]
[[Category: Phosphoprotein]]
[[Category: Sodium transport]]
[[Category: Transmembrane]]
[[Category: Transport]]