1gi7: Difference between revisions

<StructureSection load='1gi7' size='340' side='right'caption='[[1gi7]], [[Resolution|resolution]] 1.79&Aring;' scene=''>

<table><tr><td colspan='2'>[[1gi7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GI7 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=120:2-(2-OXO-1,2-DIHYDRO-PYRIDIN-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE'>120</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gi7 OCA], [https://pdbe.org/1gi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gi7 RCSB], [https://www.ebi.ac.uk/pdbsum/1gi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gi7 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>  

[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/1gi7_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gi7 ConSurf].

*[[Urokinase 3D Structures|Urokinase 3D Structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Elrod K]]

[[Category: Hatayte J]]

[[Category: Janc J]]

[[Category: Katz BA]]

[[Category: Link J]]

[[Category: Litvak J]]

[[Category: Luong C]]

[[Category: Mackman RL]]

[[Category: Rai R]]

[[Category: Rice K]]

[[Category: Rice M]]

[[Category: Sideris S]]

[[Category: Spencer J]]

[[Category: Sprengeler PA]]

[[Category: Verner E]]

[[Category: Young W]]