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[[Image:2a0s.gif|left|200px]]


{{Structure
==Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution==
|PDB= 2a0s |SIZE=350|CAPTION= <scene name='initialview01'>2a0s</scene>, resolution 2.20&Aring;
<StructureSection load='2a0s' size='340' side='right'caption='[[2a0s]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BIO:BIOPTERIN'>BIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2a0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A0S FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/6-pyruvoyltetrahydropterin_synthase 6-pyruvoyltetrahydropterin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.12 4.2.3.12] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= MAL6P1.148 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5855 Plasmodium vivax])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIO:BIOPTERIN'>BIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0720 COG0720]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0s OCA], [https://pdbe.org/2a0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a0s RCSB], [https://www.ebi.ac.uk/pdbsum/2a0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a0s ProSAT]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0s OCA], [http://www.ebi.ac.uk/pdbsum/2a0s PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2a0s RCSB]</span>
</table>
}}
== Function ==
 
[https://www.uniprot.org/uniprot/A5K2B2_PLAVS A5K2B2_PLAVS]
'''Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2A0S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0S OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/2a0s_consurf.spt"</scriptWhenChecked>
[[Category: 6-pyruvoyltetrahydropterin synthase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a0s ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Plasmodium vivax]]
[[Category: Plasmodium vivax]]
[[Category: Protein complex]]
[[Category: Bosch J]]
[[Category: Bosch, J.]]
[[Category: Hol WGJ]]
[[Category: Hol, W G.J.]]
[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
[[Category: plasmodium]]
[[Category: protein structure initiative,6-pyruvoyl tetrahydropterin synthase]]
[[Category: psi]]
[[Category: ptp]]
[[Category: sgpp]]
[[Category: structural genomic]]
[[Category: structural genomics of pathogenic protozoa consortium]]
[[Category: vivax]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:19:17 2008''

Latest revision as of 07:17, 23 August 2023

Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution

2a0s, resolution 2.20Å

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